The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic
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چکیده
The generation and analysis of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic Kwong Y Tsang, Elizabeth S Gabitzsch, Claudia Palena, Justin M David, Massimo Fantini, Anna R Kwilas, Adrian E Rice, Yvette Latchman, James W Hodge, Caroline Jochems, Romaine I Fernando, James Gulley, Ravi A Madan, Christopher R Heery, Joseph P Balint, Frank R Jones, Jeffrey Schlom
منابع مشابه
The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic.
Phenotypic heterogeneity of human carcinoma lesions, including heterogeneity in expression of tumor-associated antigens (TAAs), is a well-established phenomenon. Carcinoembryonic antigen (CEA), MUC1, and brachyury are diverse TAAs, each of which is expressed on a wide range of human tumors. We have previously reported on a novel adenovirus serotype 5 (Ad5) vector gene delivery platform (Ad5 [E1...
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